HEPARIN AS AN ANTIBACTERIAL COATING ON BIODEGRADABLE URETERAL STENTS: EXPERIMENTAL STUDY OF BRAIDSTENT®-H

Abstract INTRODUCTION The aim of this study is to assess the effectiveness heparin inhibit development early bacteriuria as a coating for biodegradable ureteral stents. MATERIAL AND METHODS BraidStent®-H stent, whose incorporated by dip coating, was chosen study. Twenty-four swine were randomly divided into two groups: 12 animals underwent unilateral placement and fitted with standard double-j stent (DJS). Bacteriuria comparatively analyzed over time consecutive urine sampling at 0, 1, 3, 6, 12, 24 48 hours. In addition, concentration released in vitro artificial 24, 48, 72, 92 120 hours determined via ELISA. RESULTS generates significantly lower rate than DJS 6 Heparin shows significant delaying effect on onset bacteriuria, reaching 100% hours, compared DJS, which takes place ELISA results reveal presence total 72 does not affect degradation device, completed weeks. CONCLUSIONS evidences an effective inhibition showing its potential antibacterial Future studies should focus long-term coatings materials.